Dimethylglycine (DMG): What it is and why people take it

Dimethylglycine (often called DMG) is a small compound your body makes in tiny amounts. It’s also sold as a supplement with claims like "boosts energy," "supports immunity," or "helps focus." Some athletes, parents of kids with developmental concerns, and people chasing better recovery all try it. But what does the science actually say, and how do you use it safely?

What dimethylglycine does and where it comes from

DMG is a derivative of the amino acid glycine. You’ll find small amounts in foods like liver, beans, and whole grains, and it’s available as capsules or powder. Researchers think DMG may affect methylation reactions and energy metabolism, which could explain why people report less fatigue and quicker recovery after exercise.

That said, evidence is mixed. A few small clinical studies and animal trials suggest benefits for exercise performance and some immune markers, but results aren’t strong or consistent. For conditions like autism, only limited and low-quality studies exist, so claims of major improvements aren’t proven.

How people commonly use DMG and typical doses

Supplement dosages vary. A common range is about 125–500 mg once or twice daily, though some protocols use up to 1,000 mg per day for short periods. Many users start low (125–250 mg) and watch for effects or side effects before increasing. Powder forms let you split doses more easily, while capsules are convenient for travel.

Think about timing: some people take DMG in the morning for energy, others split doses around workouts. If you sleep poorly after taking it, try moving the dose earlier in the day.

Safety, side effects, and drug advice

DMG is generally well tolerated. Reported side effects are rare but can include mild stomach upset, headache, or trouble sleeping. Because formal interaction studies are limited, tell your doctor if you take prescription meds—especially drugs for seizures, blood pressure, or psychiatric conditions. Pregnant or breastfeeding people should avoid DMG unless a clinician approves it.

Pick a brand that uses third-party testing (USP, NSF, or similar) so you avoid contaminated or mislabelled products. Keep doses reasonable and stop if you notice worrying symptoms.

Want to try DMG? Start with a low dose, track how you feel for a few weeks, and talk to your healthcare provider about safety and interactions. If you want deeper reads, check trusted articles on supplement research or ask your clinician for studies related to your health goals.

Curious about other supplements or medications? Browse Medzino.com for straightforward guides, safety tips, and practical dosing notes that help you make smarter choices.