Medroxyprogesterone — what it is and why people use it

One injection every three months can prevent pregnancy, but medroxyprogesterone does more than that. It’s a synthetic progestin used as the Depo‑Provera shot, in some pills, and in hormone therapy. People pick it for birth control, for managing heavy or irregular periods, and to protect the uterus when taking estrogen.

How it's used and how it works

The common birth control form is an injection: 150 mg given into the muscle every 12–13 weeks (there’s also a subcutaneous 104 mg option). If you get the shot in the first five days of a period, it works immediately. If given later, use backup contraception for 7 days. It prevents ovulation and thickens cervical mucus so sperm can’t reach an egg.

For menopausal hormone therapy, lower-dose medroxyprogesterone is paired with estrogen to stop the lining of the uterus from overgrowing. Doctors decide dose and schedule based on your needs.

Practical safety tips and side effects

Common side effects are irregular bleeding or spotting, weight changes, headaches, and mood swings. Some people notice decreased libido. Injection site pain or tenderness is normal for a few days.

A key concern with long-term use is bone mineral density. Studies show bone density can drop with prolonged use but usually recovers after stopping. If you plan to use Depo‑Provera for many years, talk to your doctor about bone health, calcium, vitamin D, and alternatives.

If you have unexplained vaginal bleeding, breast cancer, or are pregnant, you should not use medroxyprogesterone. Tell your doctor about active liver disease or a history of blood clots; though risk is lower than with estrogen, your full picture matters.

Some medicines can lower how well medroxyprogesterone works. Strong enzyme inducers — rifampin, carbamazepine, phenytoin, or herbal St. John's wort — may reduce effectiveness. Always mention other drugs and supplements you take.

Thinking about future pregnancy? Fertility often returns, but it can take several months after the last injection. Many people conceive within a year, but some wait longer. If you want to get pregnant soon, consider a different method.

Buying medroxyprogesterone online? Use licensed pharmacies and require a prescription. Check credentials, read reviews, and follow import rules for your country. Medzino has guides on safe online pharmacies and importation rules if you need more detail.

Before you start, ask your clinician: How long can I safely use this? What are signs I should call about? How will this affect my future fertility and bone health? Set a calendar reminder for your next shot and keep a copy of your vaccination card or medical notes.

Medroxyprogesterone is a reliable option for many people, but it has trade‑offs. Talk frankly with your provider and pick the method that fits your health, lifestyle, and family plans.